Chronic blockade of VEGF receptor 2 (VEGFR‐2) causes prolonged increases in VEGF expression in skeletal muscle of treadmill‐exercised mice

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

FGF-dependent regulation of VEGF receptor 2 expression in mice.

Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in ECs with disrupted FGF signaling in vitro and in vivo. ECs lacking FGF signaling became unresponsive to VEGF, caused by downregulation of VEGF receptor 2 (VEGFR2) expression afte...

متن کامل

Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.

Vascular endothelial growth factor (VEGF) blockade has been validated clinically as a treatment for human cancers, yet virtually all patients eventually develop progressive disease during therapy. In order to dissect this phenomenon, we examined the effect of sustained VEGF blockade in a model of advanced pediatric cancer. Treatment of late-stage hepatoblastoma xenografts resulted in the initia...

متن کامل

VEGF receptor interactions in vivo Interactions of VEGF isoforms with VEGFR1, VEGFR2 and Neuropilin in vivo: A computational model of human skeletal muscle

The vascular endothelial growth factor (VEGF) family of cytokines is involved in the maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new vessels. To study the pro-angiogenic activation of VEGF receptors by VEGF family members in skeletal muscle, we develop a computational model of VEGF isoforms (VEGF121, VEGF165), their cell surface receptors and the ext...

متن کامل

Exercise adaptation attenuates VEGF gene expression in human skeletal muscle.

Angiogenesis is a component of the multifactoral adaptation to exercise training, and vascular endothelial growth factor (VEGF) is involved in extracellular matrix changes and endothelial cell proliferation. However, there is limited evidence supporting the role of VEGF in the exercise training response. Thus we studied mRNA levels of VEGF, using quantitative Northern analysis, in untrained and...

متن کامل

PGC-1 mediates exercise-induced skeletal muscle VEGF expression in mice

Lotte Leick, Ylva Hellsten, Joachim Fentz, Stine S. Lyngby, Jørgen F. P. Wojtaszewski, Juan Hidalgo, and Henriette Pilegaard Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Department of Biology, Section of Molecular, Cellular, and Integrative Physiology; Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exerci...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2006

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.20.4.a717-b